Methanol Poisoning as a Critical Emergency: Clinical, Diagnostic, and Systemic Challenges in Emergency Care
Methanol Poisoning as a Critical Emergency: Clinical, Diagnostic, and Systemic Challenges in Emergency Care
DOI:
https://doi.org/10.51473/rcmos.v1i1.2023.1903Keywords:
methanol poisoning; emergency medicine; metabolic acidosis; optic neuropathy; fomepizole; hemodialysis.Abstract
Methanol poisoning is a life-threatening medical emergency characterized by severe metabolic acidosis, central nervous system injury, and a high risk of irreversible visual impairment. Although relatively infrequent in routine emergency practice, recurrent outbreaks associated with adulterated alcoholic beverages and illicit products continue to be reported worldwide, placing substantial strain on emergency care systems. This article provides a critical review of methanol poisoning pathophysiology, clinical manifestations, diagnostic strategies, and management in emergency settings. Attention is given to decision-making under diagnostic uncertainty, outbreak response, and system-level challenges. By integrating established clinical evidence and international guidelines, this review highlights early clinical suspicion, timely antidotal therapy, and hemodialysis as key determinants of patient outcomes.
Downloads
References
ASHURST, J. V.; NAKHLA, S. Methanol toxicity. In: StatPearls. Treasure Island (FL): StatPearls Publishing, 2023.
BARCELOUX, D. G. et al. American Academy of Clinical Toxicology practice guidelines on the treatment of methanol poisoning. Journal of Toxicology: Clinical Toxicology, v. 40, n. 4, p. 415–446, 2002. DOI: https://doi.org/10.1081/CLT-120006745
BENTUR, Y.; MCCANN, M.; YAREMA, M. Toxic alcohols. Critical Care Clinics, v. 28, n. 4, p. 635–654, 2012.
GALLAGHER, N. et al. The diagnosis and management of toxic alcohol poisoning in the emergency department: a review. Emergency Medicine Journal, v. 36, n. 8, p. 511–519, 2019.
HOVDA, K. E. et al. Methanol poisoning as a global public health challenge. International Journal of Surgery, v. 87, 105905, 2021.
JACOBSEN, D.; MCCARTIN, F. E. Methanol and ethylene glycol poisonings. Mechanism of toxicity, clinical course, diagnosis and treatment. Medical Toxicology, v. 1, n. 5, p. 309–334, 1986. DOI: https://doi.org/10.1007/BF03259846
KRAUT, J. A.; KURTZ, I. Toxic alcohol ingestions: clinical features, diagnosis, and management. Clinical Journal of the American Society of Nephrology, v. 3, n. 1, p. 208–225, 2008. DOI: https://doi.org/10.2215/CJN.03220807
LIBERSKI, S. M. et al. Methanol-induced optic neuropathy: a still-present problem. Neuro-Ophthalmology, v. 46, n. 1, p. 1–10, 2022.
METHANOL POISONING OUTBREAKS IN THE AMERICAS. MEDICC Review, v. 24, n. 2, p. 43–44, 2022. DOI: https://doi.org/10.37757/mr2022.v24.n2.8
MOUSAVI-ROKNABADI, R. S. et al. Methanol poisoning during the COVID-19 pandemic: a systematic scoping review. Annals of Medicine and Surgery, v. 68, 102688, 2021. DOI: https://doi.org/10.1016/j.ajem.2021.11.026
PAULOZZI, L. J.; WEISS, H. B. Methanol poisoning in the United States. Journal of Studies on Alcohol, v. 64, n. 3, p. 345–351, 2003.
PENTEL, P. R.; PETERSON, C. D. Ethanol therapy for methanol poisoning: a prospective study. Annals of Emergency Medicine, v. 10, n. 9, p. 499–504, 1981. DOI: https://doi.org/10.1016/S0196-0644(81)80175-8
SHIRAZI, F. et al. Clinical features and outcomes of methanol poisoning: a review. Iranian Journal of Medical Sciences, v. 44, n. 2, p. 81–90, 2019.
WORLD HEALTH ORGANIZATION. Methanol: health and safety guide. Geneva: WHO, 2014.
WORLD HEALTH ORGANIZATION. Preventing methanol poisoning outbreaks. Geneva: WHO, 2019.
Downloads
Published
Issue
Section
Categories
License
Copyright (c) 2023 Lucas Pedroza Daniel (Autor)

This work is licensed under a Creative Commons Attribution 4.0 International License.




