The neuroendocrine interaction in energy metabolism regulation and modulation by physical exercise: a systematic review and clinical implications
The neuroendocrine interaction in energy metabolism regulation and modulation by physical exercise: a systematic review and clinical implications
DOI:
https://doi.org/10.51473/rcmos.v1i2.2025.2089Keywords:
Exercise Endocrinology. Metabolic Flexibility. Diabetes Mellitus. Myokines. Neuroendocrine Regulation.Abstract
Energy homeostasis and metabolic regulation constitute complex physiological processes, orchestrated by an intricate network of neuroendocrine signals integrating the central nervous system, adipose tissue, pancreas, and skeletal muscle. This scientific article proposes a profound and technical analysis of the molecular and hormonal mechanisms governing metabolic flexibility, emphasizing modulation induced by physical exercise and nutritional interventions. The methodology relies on a systematic and critical bibliographic review, covering high-impact literature up to 2024. The study is structured into seven dense thematic axes, exploring everything from the pathophysiology of insulin resistance to the role of myokines and adipokines in inter-organ communication. It discusses how precise exercise prescription acts as a potent endocrine modulator capable of reversing unfavorable metabolic phenotypes. The results indicate that the clinical approach to obesity and diabetes must transcend pharmacology, incorporating lifestyle strategies grounded in chronobiology and exercise physiology. It is concluded that metabolic health education, based on robust evidence, is the most effective tool to mitigate the global burden of non-communicable chronic diseases.
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Copyright (c) 2025 Yuri Galeno Pinheiro Chaves de Freitas (Autor)
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