Recurrent Pleural Effusion of Undetermined Etiology: Case Report with Diagnostic and Prognostic Focus
Recurrent Pleural Effusion of Undetermined Etiology: Case Report with Diagnostic and Prognostic Focus
DOI:
https://doi.org/10.51473/rcmos.v1i2.2025.1245Keywords:
Pleural effusion, Malignant mesothelioma, Pleural cytology, Differential diagnosis, Pleural carcinomatosis.Abstract
Pleural effusion is a common manifestation in clinical practice and may be the first indication of benign or malignant diseases. The differentiation between transudate and exudate, according to Light's criteria, is an essential step in the initial evaluation. We present a case of massive and recurrent pleural effusion in a male patient, with insidious evolution, progressive respiratory symptoms and images compatible with pleural neoplasia. The absence of a definitive diagnosis even after extensive investigation demonstrates the clinical challenges in the etiological elucidation of these conditions. The discussion includes relevant diagnostic hypotheses, with emphasis on malignant mesothelioma and pleural carcinomatosis, as well as clinical-laboratory criteria that guide differential reasoning.
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References
Light RW. Pleural Diseases. 6th ed. Lippincott Williams & Wilkins; 2013.
Porcel JM. Pleural effusions due to malignancy. Curr Opin Pulm Med. 2021;27(4):217-223. DOI: https://doi.org/10.2174/157339808785161369
Scherpereel A, et al. Guidelines of the European Respiratory Society and the European Society of Thoracic Surgeons for the management of malignant pleural mesothelioma. Eur Respir J. 2010;35(3):479-495. DOI: https://doi.org/10.1183/09031936.00063109
Ministério da Saúde (BR). Manual de recomendações para o controle da tuberculose no Brasil. Brasília: Ministério da Saúde; 2019.
Maskell NA, Butland RJA. BTS guidelines for the investigation of a unilateral pleural effusion in adults. Thorax. 2003;58 Suppl 2: ii8–ii17. DOI: https://doi.org/10.1136/thx.58.suppl_2.ii8
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Copyright (c) 2025 Pedro Vasconcelos Aquino de Faria, Mauro Rodrigo Muller (Autor)

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