Recurrent Pleural Effusion of Undetermined Etiology: Case Report with Diagnostic and Prognostic Focus

Recurrent Pleural Effusion of Undetermined Etiology: Case Report with Diagnostic and Prognostic Focus

Authors

  • Pedro Vasconcelos Aquino de Faria Author
  • Mauro Rodrigo Muller Author

DOI:

https://doi.org/10.51473/rcmos.v1i2.2025.1245

Keywords:

Pleural effusion, Malignant mesothelioma, Pleural cytology, Differential diagnosis, Pleural carcinomatosis.

Abstract

Pleural effusion is a common manifestation in clinical practice and may be the first indication of benign or malignant diseases. The differentiation between transudate and exudate, according to Light's criteria, is an essential step in the initial evaluation. We present a case of massive and recurrent pleural effusion in a male patient, with insidious evolution, progressive respiratory symptoms and images compatible with pleural neoplasia. The absence of a definitive diagnosis even after extensive investigation demonstrates the clinical challenges in the etiological elucidation of these conditions. The discussion includes relevant diagnostic hypotheses, with emphasis on malignant mesothelioma and pleural carcinomatosis, as well as clinical-laboratory criteria that guide differential reasoning.

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Author Biographies

  • Pedro Vasconcelos Aquino de Faria

    Acadêmicos do curso de Medicina, Universidade Federal de Mato Grosso (UFMT), campus Sinop.

  • Mauro Rodrigo Muller

    Acadêmicos do curso de Medicina, Universidade Federal de Mato Grosso (UFMT), campus Sinop.

References

Light RW. Pleural Diseases. 6th ed. Lippincott Williams & Wilkins; 2013.

Porcel JM. Pleural effusions due to malignancy. Curr Opin Pulm Med. 2021;27(4):217-223. DOI: https://doi.org/10.2174/157339808785161369

Scherpereel A, et al. Guidelines of the European Respiratory Society and the European Society of Thoracic Surgeons for the management of malignant pleural mesothelioma. Eur Respir J. 2010;35(3):479-495. DOI: https://doi.org/10.1183/09031936.00063109

Ministério da Saúde (BR). Manual de recomendações para o controle da tuberculose no Brasil. Brasília: Ministério da Saúde; 2019.

Maskell NA, Butland RJA. BTS guidelines for the investigation of a unilateral pleural effusion in adults. Thorax. 2003;58 Suppl 2: ii8–ii17. DOI: https://doi.org/10.1136/thx.58.suppl_2.ii8

Published

2025-08-08

How to Cite

FARIA, Pedro Vasconcelos Aquino de; MULLER, Mauro Rodrigo. Recurrent Pleural Effusion of Undetermined Etiology: Case Report with Diagnostic and Prognostic Focus: Recurrent Pleural Effusion of Undetermined Etiology: Case Report with Diagnostic and Prognostic Focus. Multidisciplinary Scientific Journal The Knowledge, Brasil, v. 1, n. 2, 2025. DOI: 10.51473/rcmos.v1i2.2025.1245. Disponível em: https://submissoesrevistarcmos.com.br/rcmos/article/view/1245. Acesso em: 7 sep. 2025.