Extubation protocol in critically Ill patients: evidencebased strategies for a tertiary Public Hospital in the Federal District
Extubation protocol in critically Ill patients: evidencebased strategies for a tertiary Public Hospital in the Federal District
DOI:
https://doi.org/10.51473/rcmos.v1i2.2025.1821Keywords:
Intensive Care Units. Airway Extubation. Clinical Protocols.Abstract
Introduction: Extubation in intensive care units (ICUs) is a complex process with a high failure rate and significant impact on clinical outcomes. In a public tertiary hospital in the Federal District, the lack of a standardized protocol results in variations in procedures and risks to patients. The literature highlights the importance of standardization to reduce complications and mortality. Objective: Propose an institutional extubation protocol for critically ill patients in the Intensive Care Units of a public hospital in the Federal District, aiming at standardizing the criteria, conduct and care involved in this procedure. Methodology: This study consisted of a narrative review of literature with a qualitative approach. The bibliographic search was conducted in the PubMed, Scielo and Embase databases. The study was structured in three main stages: survey and analysis of the scientific literature; comparison between the current recommendations found in the literature and the extubation practices adopted in the hospital's ICUs, based on analysis of institutional documents; proposal of an institutional extubation protocol based on the verified results. Results: Evidence suggests that factors such as a positive fluid balance, the presence of abundant secretions, advanced age, and compromised nutritional status increase the risk of extubation failure. Studies show that structured and standardized protocols, including functional testing and multidisciplinary management, increase the extubation success rate, especially in surgical and neurocritical patients. Corticosteroid prophylaxis, primarily dexamethasone and methylprednisolone, has been shown to reduce post-extubation complications. Furthermore, early extubation, when clinically feasible, is associated with better outcomes. These findings supported the proposal of an institutional protocol to standardize criteria, procedures, and care for extubation in ICUs. Conclusion: Based on the study, it is possible to conclude that there are significant variations and gaps in extubation practices across the hospital's ICUs, which reinforces the need for a standardized institutional protocol. The literature review highlighted evidence-based criteria and practices that can be adapted to local circumstances, and the analysis of available resources demonstrated the feasibility of implementing a unified protocol that promotes greater safety, uniformity, and quality in the care of critically ill patients.
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References
ARCANJO, Ana Beatriz Braga; BECCARIA, Lúcia Marinilza. Factors associated with extubation failure in an intensive care unit: a case-control study. Revista Latino-Americana de Enfermagem, v. 31, p. e3864, 2023. DOI: https://doi.org/10.1590/1518-8345.6224.3865
BURNS, Karen EA et al. Frequency of Screening and Spontaneous Breathing Trial Techniques: A Randomized Clinical Trial. JAMA, v. 332, n. 21, p. 1808-1821, 2024.
CARVALHO, Haroldo Teófilo. O uso de dexametasona na prevenção da falha de extubação em unidade de terapia intensiva pediátrica: avaliação e elaboração de um protocolo na UTI Pediátrica do Hospital das Clínicas de Botucatu – Estudo clínico, randomizado e controlado. Dissertação (Mestrado) — Universidade Estadual Paulista (Unesp), 2019.
CHUANG, Chung-Yeh et al. Underweight predicts extubation failure after planned extubation in intensive care units. PLoS One, v. 18, n. 4, p. e0284564, 2023. DOI: https://doi.org/10.1371/journal.pone.0284564
CINOTTI, Raphaël et al. Extubation in neurocritical care patients: the ENIO international prospective study. Intensive Care Medicine, v. 48, n. 11, p. 1539-1550, 2022.
DESANTIS, Marianna et al. Implementation of a spontaneous awakening/spontaneous breathing trial protocol in a surgical intensive care unit: a before and after study. Minerva Anestesiologica, v. 89, n. 4, p. 306-315, 2022. DOI: https://doi.org/10.23736/S0375-9393.22.16806-9
DRES, Martin et al. Dyspnoea and respiratory muscle ultrasound to predict extubation failure. European Respiratory Journal, v. 58, n. 5, 2021. DOI: https://doi.org/10.1183/13993003.00002-2021
FENG, I.-Jung et al. Comparative efficacies of various corticosteroids for preventing postextubation stridor and reintubation: a systematic review and network meta-analysis. Frontiers in Medicine, v. 10, p. 1135570, 2023. DOI: https://doi.org/10.3389/fmed.2023.1135570
HOFMAENNER, Daniel A. et al. The doctor's point of view: eye-tracking as an investigative tool in the extubation process in intensive care units. A pilot study. Minerva Anestesiologica, v. 86, n. 11, p. 1180-1189, 2020. DOI: https://doi.org/10.23736/S0375-9393.20.14468-7
KIFLE, Natnael et al. Incidence of extubation failure and its predictors among adult patients in intensive care unit of low-resource setting: a prospective observational study. PLoS One, v. 17, n. 11, p. e0277915, 2022. DOI: https://doi.org/10.1371/journal.pone.0277915
KURIYAMA, Akira; UMAKOSHI, Noriyuki; SUN, Rao. Prophylactic corticosteroids for prevention of postextubation stridor and reintubation in adults: a systematic review and meta-analysis. Chest, v. 151, n. 5, p. 1002-1010, 2017. DOI: https://doi.org/10.1016/j.chest.2017.02.017
KURIYAMA, Akira; JACKSON, Jeffrey L.; KAMEI, Jun. Performance of the cuff leak test in adults in predicting post-extubation airway complications: a systematic review and meta-analysis. Critical Care, v. 24, p. 1-11, 2020. DOI: https://doi.org/10.1186/s13054-020-03358-8
LEWIS, Kimberley et al. Cuff leak test and airway obstruction in mechanically ventilated intensive care unit patients: a pilot randomized controlled clinical trial. Annals of the American Thoracic Society, v. 19, n. 2, p. 238-244, 2022. DOI: https://doi.org/10.1513/AnnalsATS.202103-390OC
LI, Huan et al. Decibel level of coughing as a predictor of extubation outcome in mechanically ventilated intensive care patients: a prospective, observational study. Intensive and Critical Care Nursing, v. 85, p. 103800, 2024. DOI: https://doi.org/10.1016/j.iccn.2024.103800
OTAGURO, Takanobu et al. Machine learning for prediction of successful extubation of mechanical ventilated patients in an intensive care unit: a retrospective observational study. Journal of Nippon Medical School, v. 88, n. 5, p. 408-417, 2021. DOI: https://doi.org/10.1272/jnms.JNMS.2021_88-508
PARADA-GEREDA, Henry M. et al. Effectiveness of diaphragmatic ultrasound as a predictor of successful weaning from mechanical ventilation: a systematic review and meta-analysis. Critical Care, v. 27, n. 1, p. 174, 2023. DOI: https://doi.org/10.1186/s13054-023-04430-9
TURHAN, Semin et al. Predictive Value of Serial Rapid Shallow Breathing Index Measurements for Extubation Success in Intensive Care Unit Patients. Medicina, v. 60, n. 8, p. 1329, 2024. DOI: https://doi.org/10.3390/medicina60081329
WANG, Li et al. Construction of an extubation protocol for adult tracheal intubation patients in the intensive care unit: A Delphi study. Australian Critical Care, v. 38, n. 2, p. 101111, 2025. DOI: https://doi.org/10.1016/j.aucc.2024.08.007
ZAJIC, Paul et al. Association of immediate versus delayed extubation of patients admitted to intensive care units postoperatively and outcomes: A retrospective study. PLoS One, v. 18, n. 1, p. e0280820, 2023. DOI: https://doi.org/10.1371/journal.pone.0280820
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