Aplication of nanotechnology in skin hydratation with hyaluronic acid
Aplication of nanotechnology in skin hydratation with hyaluronic acid
DOI:
https://doi.org/10.51473/rcmos.v1i1.2025.977Keywords:
Skin Hydration; Hyaluronic Acid; NanotechnologyAbstract
Skin hydration is the system of hygroscopic and lipid agents that together retain water in the skin and is
an extremely important factor when it comes to its health. A series of factors are related to the degree
of skin hydration, such as the production of lamellar lipids, those secreted by the sebaceous gland,
and the natural moisturizing factor, these substances balance the speed of transepidermal water loss
and the water retention necessary for healthy skin. One of the auxiliary components in the production
of NMF (Natural Moisturizing Factor) is hyaluronic acid, a glycosaminoglycan, and has a
hydroscopic capacity to retain up to 1000 times its weight in water, which is why it has been widely
used by the cosmetics industry to enhance the effectiveness of moisturizers. However, it is a molecule
that is originally too large to permeate the stratum corneum, requiring modifications or vectorization.
Based on these factors, the present study aimed to compare the effectiveness of vectorized and free
form hyaluronic acid, through a bibliographic review. It was conclued that the nanoencapsulated
active is capable of reaching deeper layers of the skin, thus penetrating the intercellular pathway.It
crosses the stratum corneum and reaches the dermis, and with controlled realese, itpromotes a longer
action time of the active, maintaining the water content for a longer period than the active in free
form.
Downloads
References
ANTUNES, DANIEL, AND VALÉRIA SOUZA. Ativos Dermatológicos. Red Publicações, 2019
BARRICHELO, B., SUZUKI, V.Y., KUSTER, F., ABRAHÃO, F., GONÇALVES, J.S.,
DEUTSCH,FERREIRA, L.M. (2020). Efeitos da administração oral do ácido hialurônico no envelhecimento cutâneo, uma revisão. Revista cientifica de estética.Disponível em<<https://www.researchgate.net/publication/346702986_Efeitos_da_administracao_oral_do_acido
_hialuronico_no_envelhecimento_cutaneo_uma_revisao>> Acesso em: 15 Set. 2024.
Barry. “Novel Mechanisms and Devices to Enable Successful Transdermal Drug Delivery.”
Elsevier, 2001. Disponível em:<https://www.sciencedirect.com/science/article/abs/pii/S0928098701001671> Acesso em: 20 Set.2024.
Baumann, Leslie. Dermatologia Cosmética Principios E Prática. Revinter,2004.
Beny, Mariana. “Histologia E Fisiologia Da Pele.” Cosmetics online, 2016.Disponível em:
pele_Ed-mar_abr-2013.pdf> Acesso em: 27 Set. 2024.
Bizerra, Alexa. “SISTEMAS de LIBERAÇÃO CONTROLADA: Mecanismos E Aplicações.”Revista Saúde E Meio Ambiente, 2016. Disponível em:
<https://periodicos.ufms.br/index.php/sameamb/article/view/1943> Acesso em: 01Out. 2024.
Bravo, Bruna, et al. “Benefits of Topical Hyaluronic Acid for Skin Quality and Signs of Skin Aging: From Literature Review to Clinical Evidence.”Dermatologic Therapy, vol. 35, no. 12, 21Oct. 2022. Disponível em:<https://doi.org/10.1111/dth.15903> Acesso em : 08 Out.2024. DOI: https://doi.org/10.1111/dth.15903
Chakraborty, Nayanika, et al. “Nano-Therapeutics to Treat Acne Vulgaris.”Indian Journal of Microbiology, vol. 62, no. 2, 29 Jan. 2022, pp. 167–174. Disponível em: DOI: https://doi.org/10.1007/s12088-022-01001-4
<https://doi.org/10.1007/s12088-022-01001-4> Acesso em: 15Out. 2024.
Draelos, Zoe Diana. Cosmecêuticos. 3rd ed., ELSEVIER, 2016. Disponível em
https://www.esteticistacomovoce.com.br/wpcontent/uploads/2017/11/Cosmeceuticos-ZoeDianaDraelos.pdf>> Acesso em: 28 Out. 2024.
Estelrich, Ana Robert. “Filagrina, La Hidratación Natural de La Piel.” Blog Sobre Cosmética Y Química Natural | Oushia, 8 Nov. 2018.Disponível em< <oushia.com/filagrina-la-hidratacion-natural-de-la-piel/>> Acesso em : 23 Out.2024.
Fernandes, Marta. “Nanotecnologia Na Dermofarmácia: Aplicação Ao Tratamento Da Acne.” Universidade Do Algarve, 2016. Disponível em:<https://kub.sh/a75420> Acesso em: 23 Out. 2024.
Garg, Tarun. “Current Nanotechnological Approaches for an Effective Delivery of Bio-Active Drug Molecules in the Treatment of Acne.”Artificial Cells, Nanomedicine, and Biotechnology, vol. 44, no. 1, 20 May 2014,pp. 98–105. Disponível em <<https://www.tandfonline.com/doi/full/10.3109/21691401.2014.916715>> Acesso em: 29Out. 2024. DOI: https://doi.org/10.3109/21691401.2014.916715
GOMES, R. K, DAMAZIO, M. G. Cosmetologia: Descomplicando os Princípios Ativos. 5. ed.,ver. São Paulo, SP: RED Publicações, 2017.
GONZALEZ.“Enhanced Topical Delivery of Hyaluronic Acid Encapsulated in Liposomes:NASurface-Dependent Phenomenon.” Colloids and Surfaces. B, Biointerfaces, vol. 134, Jan. 2015, pp.31–9, Disponível emhttps://doi.org/10.1016/j.colsurfb.2015.06.029.> Acesso em 15 Out. 2024 DOI: https://doi.org/10.1016/j.colsurfb.2015.06.029
Graham NB. Polymeric inserts and implants for the controlled release of drugs. British Polymer Journal. 1978;10(4):260-66. Disponível em <https://www.semanticscholar.org/paper/Polymeric-Inserts-and-Implants-for-the-Controlled-Graham/c46b29f50f651efb0313cd6e96061b1d444d3de7> DOI: https://doi.org/10.1002/pi.4980100409
Acesso em: 05 de Set. 2024
Harris, Maria. Pele Do Nascimento á Maturidade. Senac, 2016.
Jegasothy, S. Manjula, et al. “Efficacy of a New Topical Nano-Hyaluronic Acid in Humans.” TheJournal of Clinical and Aesthetic Dermatology, vol. 7, no. 3, 1 Mar. 2014, pp. 27–29,pubmed.ncbi.nlm.nih.gov/24688623/. Disponível em
https://pubmed.ncbi.nlm.nih.gov/24688623/> Acesso em: 10 set. 2024
JUNQUEIRA, L. C.; CARNEIRO, J. Biologia celular e molecular. 9.ed. Rio de Janeiro: GuanabaraKoogan, 2013. pp. 3-4, 14-15, 296. Disponível em < https://pt.slideshare.net/slideshow/junqueira-carneiro-biologia-celular-e-molecular-9-edpdf/255788478> Acesso em: 15 set. 2024
Karande P, Jain A, Ergun K, Kispersky V, Mitragotri S. Design principles of chemical penetration enhancers for transdermal drug delivery. Proc Natl Acad Sci USA.2005;102(13):4688-93. doi: 10.1073/pnas.0501176102. Disponível em DOI: https://doi.org/10.1073/pnas.0501176102
https://pubmed.ncbi.nlm.nih.gov/15774584/> Acesso em: 28 Out. 2024
Laconisi, et al. Hyaluronic Acid: A Powerful Biomolecule with Wide-Ranging Applications—ano. 12, 18 June 2023, pp. 10296–10296. Disponível em
<https://doi.org/10.3390/ijms241210296>> Acesso em : 29 Out. 2024. DOI: https://doi.org/10.3390/ijms241210296
Matalqah, Sina, et al. “Hyaluronic Acid in Nanopharmaceuticals: An Overview.”Current Issues in Molecular Biology, vol. 46, no. 9, 20 Sept. 2024, pp. 10444–10461,pmc.ncbi.nlm.nih.gov/articles/PMC11431703/.Disponível DOI: https://doi.org/10.3390/cimb46090621
em:<https://doi.org/10.3390/cimb46090621> Acesso em: 16 Nov. 2024.
Matos, Breno N, et al. “Preparações Farmacêuticas E Cosméticas Com Uso de Nanotecnologia.”Revista Brasilia Médica, 2018, Disponível em
%20nanotecnologia%20em%20cosmeticos%20(2).pdf.> Acesso em : 20 Agost. 2024
McKnight, Gerard, et al. “Physiology of the Skin.” Surgery (Oxford), vol. 40, no. 1, Dec. 2021,www.sciencedirect.com/science/article/pii/S0263931921002398, Disponível em<https://doi.org/10.1016/j.mpsur.2021.11.005.> Acesso em: 15 Agost. 2024
Moraes, B. R., Bonami, J. A., & Romualdo, L. (2017). Ácido hialurônico dentro da área de estética e cosmética. Revista saúde em foco-edição no 9. Disponível em: <https://portal.unisepe.com.br/unifia/wpcontent/uploads/sites/10001/2018/06/062_acidohialuronico.pdf> Acesso em: 20Nov. 2024.
Papakonstantinou, Eleni, et al. “Hyaluronic Acid: A Key Molecule in Skin Aging.” Dermato-Endocrinology, vol. 4, no. 3, 1 July 2012, pp. 253–258, Disponível em DOI: https://doi.org/10.4161/derm.21923
https://doi.org/10.4161/derm.21923.> Acessoem: 25 Nov. 2024
Rajkumar, Jeffrey, et al. “The Skin Barrier and Moisturization: Function, Disruption, and Mechanisms of Repair.” Skin Pharmacology and Physiology, vol. 36, no. 4, 15 Sept. 2023,Disponível em https://doi.org/10.1159/000534136.> Acessoem: 30 Nov. 2024 DOI: https://doi.org/10.1159/000534136
Rosso, James, and Jacqueline Levin. The Clinical Relevance of Maintaining the Functional Integrity of the Stratum Corneum in Both Healthy andDisease-AffectedSkin. Journal of Clinical and Aesthetic Dermatology, 2011.Disponível
em<https://pmc.ncbi.nlm.nih.gov/articles/PMC3175800/pdf/jcad_4_9_22.pdf>Acesso em: 22 Nov.2024.
Scarpino, Rodolfo, and Maria Berardo. “Influência Da Formulação Dermocosmética Na Permeação de Substâncias Ativas Para O Controle de Hipercromias Cutâneas.” Repositorio.usp.br, 2020,repositorio.usp.br/item/003048087.Disponível em
https://repositorio.usp.br/item/003048087> Accesso em: 10 Apr. 2025.
Shang, Lin, et al. “Recent Applications and Molecular Mechanisms of Hyaluronic Acid in Skin Aging and Wound Healing.” Medicine in Novel Technology and Devices, vol. 23, 1 Sept. 2024, pp.100320–100320.Disponível em< https://doi.org/10.1016/j.medntd.2024.100320> Acesso em: 24 DOI: https://doi.org/10.1016/j.medntd.2024.100320
Nov. 2024.
Silva JA, Apolinário AC, Souza MSR, Damasceno BPGL, Medeiros ACD. Administração cutânea de fármacos: desafios e estratégias para o desenvolvimento de formulações transdérmicas. Rev. Ciênc Farm Básica Apl. 2010;31(3):125-31. Disponível em <https://rcfba.fcfar.unesp.br/index.php/ojs/article/view/357> Acesso em: 20 Out. 2024
Shigefuji, Miki, and Yoshihiro Tokudome. “Nanoparticulation of HyaluronicAcid: A New Skin Penetration Enhancing Polyion Complex Formulation: Mechanism and Future Potential.”Materialia, vol. 14, Dec. 2020, p. 100879.Disponível em: DOI: https://doi.org/10.1016/j.mtla.2020.100879
<https://doi.org/10.1016/j.mtla.2020.100879> Acesso em: 24Nov. 2024.
Smejkalova, Daniela, et al. Hyaluronan (Hyaluronic Acid): A Natural Moisturizer for Skin Care. 1Sept.2015,www.researchgate.net/publication/272175669_Hyaluronan_Hyaluronic_Acid_a_natural_moisturizer_for_skin_care. Disponível em
https://www.researchgate.net/publication/272175669_Hyaluronan_Hyaluronic_Acid_a_natural_moisturizer_for_skin_care> Acesso em : 20 Out. 2024
Souza, et al. “| Cosmetics Online Brasil.” Cosmetics Online, 2020. Disponível em: Acesso em: 26 Nov. 2024.
Tokudome, Yoshihiro, et al. “A New Strategy for the Passive Skin Delivery of Nanoparticulate,High Molecular Weight Hyaluronic Acid Prepared by a PolyionComplex Method.” Scientific Reports, vol. 8, no. 1, 5 Feb. 2018.Disponível em: < https://www.nature.com/articles/s41598-018- DOI: https://doi.org/10.1038/s41598-018-20805-3
-3>Acesso em: 28 Nov. 2024.
Universidade Federal de Alfenas. Pele E Anexos – Histologia Interativa.” Disponível em Acesso em: 12 de Set. 2024
“Valachová 2024 Hyaluronic Acid and Chitosan-Based - International Journal of Biological -Studocu.” Studocu, 2024. Disponível em
based/120673346.> Accesso em: 10 Out. 2024.
Vázquez-González, Martha L, et al. “Enhanced Topical Delivery of Hyaluronic AcidEncapsulated in Liposomes: A Surface-Dependent Phenomenon.” Elsevier, 2015. Disponível em <https://www.sciencedirect.com/science/article/abs/pii/S0927776515004026> Acesso em: 2 Out.2024
ZHOU. “Expression of Concern: . Extracellular Vesicles of Commensal Skin Microbiota Alleviate Cutaneous Inflammation in Atopic Dermatitis Mouse Model by Re-Establishing Skin Homeostasis. J Invest Derm Doi:10.1016/J.jid.2023.02.023.” Journal of Investigative Dermatology, DOI: https://doi.org/10.1016/j.jid.2023.02.023
Mar. 2024, https://doi.org/10.1016/j.jid.2024.03.001. Disponível em DOI: https://doi.org/10.1016/j.jid.2024.03.001
https://pubmed.ncbi.nlm.nih.gov/36907322/> Acesso em: 5 Out. 2024.
Downloads
Additional Files
Published
Issue
Section
Categories
License
Copyright (c) 2025 Marcella Yasmin Peixoto da Costa, Márcia Freire dos Reis Gorny, Felipe Scholz Ramos, Isabella Tereza Ferro Barbosa (Autor)
This work is licensed under a Creative Commons Attribution 4.0 International License.
This work is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0). This means you are free to:
- Share — copy and redistribute the material in any medium or format.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
The use of this material is conditioned upon proper attribution to the original author(s), providing a link to the license, and indicating if changes were made. The license does not require permission from the author or the publisher as long as these conditions are met.
The Creative Commons license logo is displayed permanently in the footer of the journal.
The copyright of the manuscript can be retained by the authors without restrictions and can be requested at any time, even after publication in the journal.
