The intersection between metabolic programming, immunological maturation, and rational therapeutics in the first thousand days: an integrative pediatric approach
The intersection between metabolic programming, immunological maturation, and rational therapeutics in the first thousand days: an integrative pediatric approach
DOI:
https://doi.org/10.51473/rcmos.v1i1.2025.1951Keywords:
First Thousand Days. Nutritional Immunomodulation. Rational Use of Medicines. Gut Microbiota. Fever in Pediatrics.Abstract
This scientific article proposes an in-depth analysis of the physiology of infant development during the first thousand days of life, focusing on the triad: nutrition, immunity, and pharmacology. The research problem addresses how early nutritional intervention and inadequate management of febrile and infectious processes can negatively impact the child's future chronic health. The general objective is to correlate the quality of complementary feeding and the maintenance of gut microbiota homeostasis with immunological competence, advocating for a clinical practice based on the rational use of medications. The methodology is based on a high-level narrative bibliographic review, integrating knowledge of immunology, nutrology, and pharmacodynamics, based on academic guidelines and medical consensus up to 2021. The results indicate that "fever phobia" and inadequate complementary feeding are risk factors for dysbiosis and immune dysregulation. It is concluded that pediatric practice should prioritize health education and environmental modulation over excessive pharmacological intervention, aiming at the primary prevention of atopy and metabolic diseases.
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References
ALVES, J. G. B. et al. A importância da nutrição nos primeiros 1000 dias de vida. Revista Brasileira de Saúde Materno Infantil, Recife, v. 19, n. 2, 2019.
BRASIL. Ministério da Saúde. Guia alimentar para crianças brasileiras menores de 2 anos. Brasília: Ministério da Saúde, 2019.
GOLDENBERG, R. L. et al. The first 1000 days: nutrition and brain development. American Journal of Clinical Nutrition, v. 104, supl. 1, p. 3–30, 2016.
NELSON, W. E. et al. Nelson textbook of pediatrics. 21. ed. Philadelphia: Elsevier, 2020.
SAFE TO SLEEP. Interactive campaign tools. National Institute of Child Health and Human Development, 2021.
SCHMITT, B. D. Fever phobia: misconceptions of parents about fevers. American Journal of Diseases of Children, v. 134, n. 2, p. 176–181, 1980.
SOCIEDADE BRASILEIRA DE PEDIATRIA. Tratado de pediatria. 4. ed. Barueri: Manole, 2017.
SOCIEDADE BRASILEIRA DE PEDIATRIA. Departamento Científico de Infectologia. Guia prático de conduta em febre. Rio de Janeiro: SBP, 2021.
VICTORA, C. G. et al. Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect. The Lancet, v. 387, n. 10017, p. 475–490, 2016.
WORLD HEALTH ORGANIZATION. Guideline: protecting, promoting and supporting breastfeeding in facilities providing maternity and newborn services. Geneva: WHO, 2017.
YANG, I. et al. The infant microbiome: implications for infant health and neurocognitive development. Nursing Research, v. 65, n. 1, p. 76–88, 2016.
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Copyright (c) 2025 Gisele Luciana Carvalho (Autor)
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