Perihilar cholangiocarcinoma: case report and surgical approach

Perihilar cholangiocarcinoma: case report and surgical approach

Authors

  • Lucas Rocha da Silva Hospital Universitário Getúlio Vargas Author
  • Brigida Thaine Fernandes Cabral Hospital Universitário Getúlio Vargas Author
  • Leandro Moraes Costa Hospital Universitário Getúlio Vargas Author
  • Leonardo Simão Coelho Guimarães Hospital Universitário Getúlio Vargas Author
  • Danielle Alcântara Barbosa Macedo Hospital Universitário Getúlio Vargas Author

DOI:

https://doi.org/10.51473/rcmos.v1i1.2026.2005

Keywords:

Cholangiocarcinoma, Biliary neoplasms, Hepatic surgery

Abstract

Cholangiocarcinoma is a rare and aggressive malignant neoplasm arising from the biliary epithelium. Diagnosis is often delayed due to nonspecific symptoms. We report the case of a 59-year-old female presenting with epigastric and right upper quadrant pain for one year, associated with postprandial nausea and vomiting, without jaundice or weight loss. Laboratory tests showed mild hyperbilirubinemia and normal tumor markers. Computed tomography and magnetic resonance cholangiography revealed an infiltrative lesion in hepatic segment IV with intraductal extension involving the hepatic hilum, classified as Bismuth-Corlette IIIB. Liver biopsy confirmed moderately differentiated adenocarcinoma. The patient underwent partial hepatectomy with lymphadenectomy of the hepatic pedicle, achieving tumor-free margins. Postoperative recovery was uneventful. Surgical resection with curative intent remains the cornerstone of treatment when feasible. 

Downloads

Download data is not yet available.

Author Biographies

  • Lucas Rocha da Silva, Hospital Universitário Getúlio Vargas

    Hospital Universitário Getúlio Vargas

  • Danielle Alcântara Barbosa Macedo, Hospital Universitário Getúlio Vargas

    Orientador

References

CARINGI, Silvio et al. Hot topics in the surgical treatment of intrahepatic cholangiocarcinoma: a narrative review of current managements. Cancers, Basel, v. 17, n. 3, p. 127, 2025. DOI: 10.3390/cancers1703127. Disponível em: https://www.mdpi.com/2072-6694/17/3/127. Acesso em: 02 fev. 2026.

LIGUORI, Carolina et al. Is it a new era for intrahepatic cholangiocarcinoma? Critical Reviews in Oncology/Hematology, Amsterdam, v. 215, p. 104923, 2025. DOI: 10.1016/j.critrevonc.2025.104923. Disponível em: https://www.sciencedirect.com. Acesso em: 02 fev. 2026. DOI: https://doi.org/10.1016/j.critrevonc.2025.104923

COLANGELO, Matteo et al. Management of intrahepatic cholangiocarcinoma: a review for clinicians. Gastroenterology Report, Oxford, v. 13, p. goaf005, 2025. DOI: 10.1093/gastro/goaf005. Disponível em: https://academic.oup.com. Acesso em: 02 fev. 2026. DOI: https://doi.org/10.1093/gastro/goaf005

Published

2026-02-03

How to Cite

SILVA, Lucas Rocha da; CABRAL, Brigida Thaine Fernandes; COSTA, Leandro Moraes; GUIMARÃES, Leonardo Simão Coelho; MACEDO, Danielle Alcântara Barbosa. Perihilar cholangiocarcinoma: case report and surgical approach: Perihilar cholangiocarcinoma: case report and surgical approach. Multidisciplinary Scientific Journal The Knowledge, Brasil, v. 1, n. 1, 2026. DOI: 10.51473/rcmos.v1i1.2026.2005. Disponível em: https://submissoesrevistarcmos.com.br/rcmos/article/view/2005. Acesso em: 21 mar. 2026.